The Impact of Recombinant Growth Hormone on Quality of Life for Adult Growth Hormone Deficiency: A Systematic Review
First, we conducted a scoping review that looks at the existing research on using recombinant human growth hormone (rhGH) in adults who have had a traumatic brain injury (TBI).We found and reviewed 11 studies where rhGH was given to people after TBI — including those with diagnosed growth hormone deficiency and those with broader growth hormone signaling issues — and examined outcomes like quality of life, mood, fatigue, physical function, cognition, biochemical markers, and brain imaging changes. Across these studies, rhGH therapy was associated with improvements in things like mood, fatigue, physical performance, cognitive function, and neuroimaging measures, even in some patients who wouldn’t traditionally qualify as growth hormone deficient; the review concludes that rhGH may benefit people after TBI but that larger controlled studies are still needed to confirm these effects.
